The AKAP11 Polyclonal Antibody (PACO03388) is a valuable tool for researchers studying AKAP11, a scaffolding protein involved in cell signaling and protein localization within the cell. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the AKAP11 protein, this antibody enables the detection and analysis of AKAP11 in a variety of cell types, making it an essential tool for studies in cell biology and signal transduction research. AKAP11, also known as A-kinase anchor protein 220, is known to play a crucial role in organizing signaling complexes and regulating the localization of proteins involved in signal transduction pathways.
Its involvement in cell signaling makes it an attractive target for research in various fields, including cancer biology, developmental biology, and neuroscience. Researchers aiming to understand the molecular mechanisms underlying cellular signaling processes can benefit greatly from the use of the AKAP11 Polyclonal Antibody in their experiments.
Antibody Name:
AKAP11 Antibody
Antibody SKU:
PACO03388
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human AKAP 220.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
AKAP11; AKAP220; KIAA0629; A-kinase anchor protein 11; AKAP-11; A-kinase anchor protein 220 kDa; AKAP 220; hAKAP220; Protein kinase A-anchoring protein 11; PRKA11
UniProt Protein Function:
AKAP11: Binds to type II regulatory subunits of protein kinase A and anchors/targets them. Belongs to the AKAP110 family.Protein type: Motility/polarity/chemotaxis; Adaptor/scaffoldChromosomal Location of Human Ortholog: 13q14.11Cellular Component: microtubule organizing center; peroxisomeMolecular Function: protein kinase A binding; protein phosphatase 1 binding
UniProt Protein Details:
NCBI Summary:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
A-kinase anchor protein 11; A-kinase anchor protein 220 kDa; a kinase anchor protein 220 kDa; A-kinase anchoring protein, 220kDa; protein kinase A anchoring protein 11; protein kinase A-anchoring protein 11; protein phosphatase 1, regulatory subunit 44
UniProt Protein Name:
A-kinase anchor protein 11
UniProt Synonym Protein Names:
A-kinase anchor protein 220 kDa; AKAP 220; hAKAP220; Protein kinase A-anchoring protein 11; PRKA11
