The AK1 Polyclonal Antibody (CAB13460) is a valuable tool for researchers studying AK1, a key enzyme involved in energy metabolism. This antibody, produced in rabbits, exhibits a high level of reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the AK1 protein, researchers can easily detect and analyze AK1 expression in a variety of cell types, making it an essential component of studies focused on cellular energy regulation and metabolism.AK1, also known as adenylate kinase 1, plays a crucial role in maintaining cellular energy balance by facilitating the transfer of phosphate groups between nucleotides.
Dysregulation of AK1 has been linked to various metabolic disorders, making it an attractive target for research in the fields of metabolism, bioenergetics, and mitochondrial function. Understanding the mechanisms by which AK1 functions can provide insights into the development of potential therapies for metabolic diseases and mitochondrial disorders.
Product Name:
AK1 Rabbit Polyclonal Antibody
SKU:
CAB13460
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human AK1 (NP_000467.1).
This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene shares readthrough transcripts with the upstream ST6GALNAC6 gene.
Purification Method:
Affinity purification
Gene ID:
203
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using AK1 Rabbit pAb (CAB13460) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
