The AIRE Polyclonal Antibody (CAB1767) is a crucial tool for researchers studying the autoimmune regulator protein (AIRE) in immune regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By specifically binding to the AIRE protein, this antibody enables accurate detection and analysis in various cell types, providing valuable insights into the mechanisms underlying autoimmune diseases and immune system function.AIRE is a key player in maintaining self-tolerance by regulating the expression of tissue-specific antigens in the thymus, thereby preventing the development of autoimmune disorders.
Dysregulation of AIRE has been implicated in conditions such as autoimmune polyendocrine syndrome type 1 (APS-1) and type 1 diabetes. By studying the role of AIRE using this antibody, researchers can gain a better understanding of the immune response dysregulation in autoimmune diseases, paving the way for novel therapeutic approaches.
Product Name:
AIRE Rabbit Polyclonal Antibody
SKU:
CAB1767
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 30-130 of human AIRE (NP_000374.1).
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Purification Method:
Affinity purification
Gene ID:
326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AIRE antibody (CAB1767) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
