AIRE Rabbit Polyclonal Antibody (CAB1767)
- SKU:
- CAB1767
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | AIRE Rabbit Polyclonal Antibody |
SKU: | CAB1767 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 30-130 of human AIRE (NP_000374.1). |
Sequence: | HALA DHDV VPED KFQE TLHL KEKE GCPQ AFHA LLSW LLTQ DSTA ILDF WRVL FKDY NLER YGRL QPIL DSFP KDVD LSQP RKGR KPPA VPKA LVPP PRLP T |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | APS1; APSI; PGA1; AIRE1; APECED; AIRE |
Positive Sample: | MCF7,U-937,HT-29,OVCAR3,SW620,Mouse kidney,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 58kDa |
Observed MW: | 55kDa |
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Purification Method: | Affinity purification |
Gene ID: | 326 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |