The AIPL1 Polyclonal Antibody (CAB14113) is a valuable research tool designed for studying AIPL1, a protein involved in the visual cycle and retinal development. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.AIPL1, also known as aryl hydrocarbon receptor-interacting protein-like 1, plays a crucial role in the function of photoreceptor cells in the retina. Mutations in the AIPL1 gene have been associated with inherited retinal degenerative diseases such as Leber congenital amaurosis and retinitis pigmentosa. Understanding the function of AIPL1 is essential for unraveling the mechanisms underlying these disorders and developing potential therapeutic strategies.
With its high specificity and sensitivity, the AIPL1 Polyclonal Antibody enables accurate detection and analysis of AIPL1 protein expression in various cell types and tissues. Its application in research on retinal diseases and visual function makes it an indispensable tool for scientists working in the fields of ophthalmology, genetics, and molecular biology. Unlock the mysteries of AIPL1 with this reliable antibody and further your understanding of retinal development and degenerative disorders.
Product Name:
AIPL1 Rabbit Polyclonal Antibody
SKU:
CAB14113
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human AIPL1 (NP_055151.3).
Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23746
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AIPL1 antibody (CAB14113) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
