The AIM2 Polyclonal Antibody is a valuable tool for researchers studying the AIM2 protein, a key component of the innate immune system response to cytoplasmic DNA. This antibody is raised in rabbits, providing high reactivity with human samples and validated for use in Western blot applications. By binding to the AIM2 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in immunology and infectious disease research.The AIM2 protein is essential for sensing cytoplasmic DNA and activating the inflammasome, leading to the production of pro-inflammatory cytokines and the induction of pyroptosis, a form of inflammatory cell death.
Understanding the role of AIM2 in the immune response to pathogens is crucial for developing new therapies to combat infectious diseases and inflammatory conditions. The AIM2 Polyclonal Antibody provides researchers with a reliable tool to study the function and regulation of this critical immune sensor.
Product Name:
Aim2 Polyclonal Antibody
SKU:
CAB22874
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of mouse Aim2 (NP_001013801.2).
Enables double-stranded DNA binding activity and identical protein binding activity. Involved in positive regulation of macromolecule metabolic process; pyroptosis; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Located in cytoplasm. Part of AIM2 inflammasome complex. Orthologous to human AIM2 (absent in melanoma 2).
Purification Method:
Affinity purification
Gene ID:
383619
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Rat spleen, using Aim2 antibody (CAB22874) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
