Aif1 Antibody (PACO24823)
- SKU:
- PACO24823
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Aif1 Antibody (PACO24823)
The AIF1 Polyclonal Antibody (PAC024823) is a valuable tool for researchers studying AIF1, a protein involved in immune regulation and cellular signaling pathways. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the AIF1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.
AIF1, also known as allograft inflammatory factor 1, is a key player in immune responses and has been implicated in various diseases such as cancer and autoimmune disorders. By understanding the role of AIF1 in immune modulation, researchers can uncover new therapeutic targets for these conditions. The AIF1 Polyclonal Antibody is a valuable tool for advancing our knowledge of AIF1's function and its potential implications in disease pathology.
| Antibody Name: | Aif1 Antibody (PACO24823) |
| Antibody SKU: | PACO24823 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Allograft inflammatory factor 1 protein (2-147AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Aif1 antibody at 2µg/ml + THP-1 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 17 kDa Observed band size: 17 kDa . |
| Background: | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Synonyms: | Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1), Aif1, Iba1 |
| UniProt Protein Function: | AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalCellular Component: actin filament; cell projection; cytoplasm; cytoskeleton; cytosol; lamellipodium; membrane; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; plasma membrane; ruffleMolecular Function: actin binding; actin filament binding; calcium ion binding; metal ion binding; protein bindingBiological Process: actin filament bundle formation; actin filament polymerization; microglial cell activation; negative regulation of apoptosis; negative regulation of smooth muscle cell proliferation; phagocytosis, engulfment; positive regulation of cell migration; positive regulation of muscle hyperplasia; positive regulation of nitric oxide biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; Rac protein signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O70200 |
| NCBI GenInfo Identifier: | 9506379 |
| NCBI Gene ID: | 11629 |
| NCBI Accession: | NP_062340.1 |
| UniProt Secondary Accession: | O70200 |
| UniProt Related Accession: | O70200 |
| Molecular Weight: | 16,911 Da |
| NCBI Full Name: | allograft inflammatory factor 1 |
| NCBI Synonym Full Names: | allograft inflammatory factor 1 |
| NCBI Official Symbol: | Aif1Â Â |
| NCBI Official Synonym Symbols: | G1; Iba1; AIF-1; AI607846; D17H6S50EÂ Â |
| NCBI Protein Information: | allograft inflammatory factor 1 |
| UniProt Protein Name: | Allograft inflammatory factor 1 |
| UniProt Synonym Protein Names: | Ionized calcium-binding adapter molecule 1 |
| Protein Family: | Apoptosis-inducing factor |
| UniProt Gene Name: | Aif1Â Â |
| UniProt Entry Name: | AIF1_MOUSE |
Related Products
AIF1/IBA1 Rabbit Monoclonal Antibody (CAB19776)
€139 - €419
Rat AIF1 ELISA Kit
€649
NAIF1 Rabbit Polyclonal Antibody (CAB15217)
€139 - €419
Human AIF1 / Allograft inflammatory factor 1 ELISA Kit
€599
Porcine Allograft inflammatory factor 1 (AIF1) ELISA Kit (PREB0331)
€699