AIF Rabbit Monoclonal Antibody (CAB19536)
- SKU:
- CAB19536
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | AIF Rabbit Monoclonal Antibody |
SKU: | CAB19536 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human AIF (O95831). |
Sequence: | RRVE HHDH AVVS GRLA GENM TGAA KPYW HQSM FWSD LGPD VGYE AIGL VDSS LPTV GVFA KATA QDNP KSAT EQSG TGIR SESE TESE ASEI TIPP STPA V |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | AIF; AUNX1; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; SEMDHL |
Positive Sample: | 293T,U-251MG,HeLa,Mouse brain,Mouse kidney,Mouse heart,Rat heart,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion inner membrane, Mitochondrion intermembrane space, Nucleus, perinuclear region. |
Calculated MW: | 67kDa |
Observed MW: | 67kDa |
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Purification Method: | Affinity purification |
Gene ID: | 9131 |
Clone Number: | ARC0015 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |