AIF Polyclonal Antibody (CAB0811)
- SKU:
- CAB0811
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
- IF
Description
Product Name: | AIF Polyclonal Antibody |
SKU: | CAB0811 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_004199.1). |
Sequence: | FPEK GNMG KILP EYLS NWTM EKVR REGV KVMP NAIV QSVG VSSG KLLI KLKD GRKV ETDH IVAA VGLE PNVE LAKT GGLE IDSD FGGF RVNA ELQA RSNI WVAG DAAC FYDI KLGR RRVE HHDH AVVS GRLA GENM TGAA KPYW HQSM FWSD LGPD VGYE AIGL VDSS LPTV GVFA KATA QDNP KSAT EQSG TGIR SESE TESE ASEI TIPP STPA VPQA PVQG EDYG KGVI FYLR DKVV VGIV LWNI FNRM PIAR KIIK DGEQ HEDL NEVA KLFN IHED |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AIF; AUNX1; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; SEMDHL |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion inner membrane, Mitochondrion intermembrane space, Nucleus, perinuclear region. |
Calculated MW: | 67kDa |
Observed MW: | 60kDa |
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Purification Method: | Affinity purification |
Gene ID: | 9131 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |