The AIDA Antibody (PACO63839) is a polyclonal antibody specifically designed for research involving CD300A, a cell surface molecule known for its role in immune regulation and inhibiting immune responses. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CD300A protein, this antibody allows for detection and analysis in various cell types, making it an ideal tool for studies in immunology and cancer research.
CD300A, also referred to as an immune inhibitory receptor, is a key player in immune homeostasis by regulating inflammation and inhibiting allergic reactions. Its importance in modulating immune responses has made it a valuable target for research in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CD300A is essential for advancing therapies that aim to harness or modulate immune function in these disease contexts.
Antibody Name:
AIDA Antibody (PACO63839)
Antibody SKU:
PACO63839
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Axin interactor, dorsalization-associated protein (14-306AA)
Immunofluorescence staining of U251 cells with PACO63839 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
Synonyms:
Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist), AIDA, C1orf80
UniProt Protein Function:
AIDA: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling. Belongs to the AIDA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cell development/differentiationChromosomal Location of Human Ortholog: 1q41Molecular Function: protein bindingBiological Process: dorsal/ventral pattern formation; negative regulation of JNK activity; negative regulation of JNK cascade; regulation of protein homodimerization activity
