The AICDA Polyclonal Antibody (CAB16217) is a valuable tool for researchers studying AICDA, an enzyme essential for somatic hypermutation and class-switch recombination in B cells. This antibody is produced in rabbits and is highly specific for human samples, making it an ideal choice for research involving AICDA.AICDA, also known as activation-induced cytidine deaminase, plays a crucial role in the adaptive immune response by introducing mutations in immunoglobulin genes, leading to antibody diversity and affinity maturation. Dysregulation of AICDA has been implicated in various autoimmune diseases and lymphoid malignancies, highlighting its significance in immunology research.
This polyclonal antibody is validated for use in Western blot applications, enabling detection and analysis of AICDA in different cell types and tissues. By targeting the AICDA protein, researchers can gain insights into the mechanisms underlying antibody diversification and immune response regulation, ultimately contributing to the development of novel therapies for immune-related disorders.
Product Name:
AICDA Polyclonal Antibody
SKU:
CAB16217
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide of mouse AICDA
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
Aid; Arp2; AICDA
Positive Sample:
Rat spleen
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
24kDa
Observed MW:
24kDa
Enables cytidine deaminase activity. Involved in cytidine deamination and isotype switching. Acts upstream of or within cellular response to lipopolysaccharide and defense response to bacterium. Predicted to be part of protein-containing complex. Predicted to be active in P-body and nucleus. Is expressed in several structures, including immune system; lower urogenital tract; lung; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase).
Purification Method:
Affinity purification
Gene ID:
11628
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat spleen, using AICDA Rabbit pAb (CAB16217) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
