AICDA Antibody (PACO20932)
- SKU:
- PACO20932
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
AICDA Antibody (PACO20932)
The AICDA Polyclonal Antibody (PAC020932) is a valuable tool for research on AICDA, an enzyme essential for antibody diversification through somatic hypermutation and class switch recombination. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the AICDA protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.AICDA, also known as activation-induced cytidine deaminase, plays a crucial role in the generation of antibody diversity by inducing DNA mutations in immunoglobulin genes.
Its involvement in the immune response makes it a key player in the development of immune-based therapies and understanding antibody-mediated diseases. Research on AICDA is instrumental in advancing our knowledge of antibody diversification mechanisms and may lead to breakthroughs in treating autoimmune disorders, infectious diseases, and cancer.
| Antibody Name: | AICDA Antibody (PACO20932) |
| Antibody SKU: | PACO20932 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human AICDA |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20932(AICDA Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). |
| Synonyms: | activation-induced cytidine deaminase |
| UniProt Protein Function: | AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. |
| UniProt Protein Details: | Protein type:EC 3.5.4.38; Hydrolase Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasm; exosome (RNase complex); nucleus Molecular Function:protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing Disease: Immunodeficiency With Hyper-igm, Type 2 |
| NCBI Summary: | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9GZX7 |
| NCBI GenInfo Identifier: | 23813666 |
| NCBI Gene ID: | 57379 |
| NCBI Accession: | Q9GZX7.1 |
| UniProt Related Accession: | Q9GZX7 |
| Molecular Weight: | |
| NCBI Full Name: | Single-stranded DNA cytosine deaminase |
| NCBI Synonym Full Names: | activation induced cytidine deaminase |
| NCBI Official Symbol: | AICDAÂ Â |
| NCBI Official Synonym Symbols: | AID; ARP2; CDA2; HIGM2; HEL-S-284Â Â |
| NCBI Protein Information: | single-stranded DNA cytosine deaminase |
| UniProt Protein Name: | Single-stranded DNA cytosine deaminase |
| UniProt Synonym Protein Names: | Activation-induced cytidine deaminase; Cytidine aminohydrolase |
| Protein Family: | AIDA-I autotransporter |
| UniProt Gene Name: | AICDAÂ Â |
| UniProt Entry Name: | AICDA_HUMAN |
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