The AHSP Polyclonal Antibody (CAB6465) is a powerful tool for researchers studying AHSP, a key protein involved in iron metabolism and hemoglobin production. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting AHSP in various sample types, making it ideal for Western blot applications.AHSP, or alpha-hemoglobin-stabilizing protein, plays a crucial role in stabilizing alpha-globin chains and preventing their degradation, ensuring proper hemoglobin formation and function. Dysregulation of AHSP has been linked to various blood disorders, including thalassemia and anemia, making it a valuable target for research in hematology and transfusion medicine.
By utilizing the AHSP Polyclonal Antibody, researchers can investigate the expression and function of AHSP in different cell types and disease contexts, advancing our understanding of iron homeostasis and hemoglobin synthesis. This antibody provides a reliable tool for studying AHSP biology and potential therapeutic targets for hematological disorders.
Product Name:
AHSP Rabbit Polyclonal Antibody
SKU:
CAB6465
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-102 of human AHSP (NP_057717.1).
This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51327
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AHSP antibody (CAB6465) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
