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aHLA-ABC monoclonal antibody (APC) (AGIM0488)

SKU:
AGIM0488
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
W6/32
Conjugation:
APC
Applications:
FC
$215
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Description

system_update_altDatasheet
Product Name:aHLA-ABC monoclonal antibody (APC)
Product Code:AGIM0488
Size:100 µL
Reactivity:Human
Clone:W6/32
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P04439
Background:The W6/32 monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, C. MHC class I antigens associated with beta 2-microglobulin are expressed by all human nucleated cells and are central in cell-mediated immune response and tumor surveillance. W6/32 mAb recognizes a non-polymorphic epitope shared among products of the HLA-A, B, and C loci and immunoprecipitates both 43 kDa and 11-12 kDa chains. Crossreactivity is also seen in baboon, rhesus and cynomolgus monkey.
UniProt Protein Function:Involved in the presentation of foreign antigens to the immune system.
NCBI Summary:HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P04439
NCBI GenInfo Identifier:13124681
NCBI Gene ID:3105
NCBI Accession:P01891.4
UniProt Secondary Accession:P04439,O19673, O19695, O19794, O19795, O43907, O77938 O98010, P10315, P79505, Q9MYA5, Q9MYC4,
UniProt Related Accession:P01891,P01892,P04439,P05534,P10314,P10316,P13746,P16188,P16189,P16190
Molecular Weight:40,909 Da
NCBI Full Name:HLA class I histocompatibility antigen, A-68 alpha chain
NCBI Synonym Full Names:major histocompatibility complex, class I, A
NCBI Official Symbol:HLA-A  
NCBI Official Synonym Symbols:HLAA  
NCBI Protein Information:HLA class I histocompatibility antigen, A-1 alpha chain; LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-1 alpha chain
UniProt Protein Name:HLA class I histocompatibility antigen, A-68 alpha chain
UniProt Synonym Protein Names:Aw-68; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*68
Protein Family:HLA class I histocompatibility antigen
UniProt Gene Name:HLA-A  

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