The AGXT Polyclonal Antibody (CAB8397) is a valuable tool for researchers studying the AGXT protein, which is involved in various metabolic pathways and liver function. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the AGXT protein, allowing for precise detection and analysis in a variety of cell types.AGXT, also known as alanine-glyoxylate aminotransferase, plays a crucial role in the detoxification of glyoxylate, a harmful substance that can accumulate in the body and lead to various health issues.
Dysregulation of AGXT activity has been linked to conditions such as primary hyperoxaluria, a rare genetic disorder that affects the kidneys and can result in kidney stones and kidney damage.By studying the function of AGXT and its role in metabolic processes, researchers can gain insights into the mechanisms underlying certain diseases and potentially develop targeted therapies to treat or prevent them. The AGXT Polyclonal Antibody is an essential tool for investigating the function and regulation of this important protein in both normal and pathological conditions.
Product Name:
AGXT Rabbit Polyclonal Antibody
SKU:
CAB8397
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 183-392 of human AGXT (NP_000021.1).
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.
Purification Method:
Affinity purification
Gene ID:
189
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using AGXT Rabbit pAb (CAB8397) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
