The AGXT Polyclonal Antibody (PAC024811) is a valuable tool for researchers studying AGXT, a vital enzyme involved in the metabolism of amino acids. This antibody, produced in rabbits, is highly specific to human AGXT and has been validated for use in Western blot applications. By binding to the AGXT protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in metabolic disorders and liver disease research.AGXT, also known as alanine-glyoxylate aminotransferase, is essential for the breakdown of amino acids and the detoxification of harmful substances in the liver.
Dysregulation of AGXT activity has been implicated in conditions such as primary hyperoxaluria, a rare genetic disorder that can lead to kidney stones and other complications. By gaining insights into the function of AGXT, researchers can uncover potential therapeutic strategies for managing these conditions and improving patient outcomes.
Antibody Name:
Agxt Antibody (PACO24811)
Antibody SKU:
PACO24811
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Serine--pyruvate aminotransferase, mitochondrial protein (25-414AA)
AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.44; Motility/polarity/chemotaxis; Transferase; EC 2.6.1.51; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonineCellular Component: mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisomeMolecular Function: alanine-glyoxylate transaminase activity; amino acid binding; catalytic activity; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity; transferase activityBiological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus
