The AGTR2 Polyclonal Antibody (CAB21999) is a valuable tool for researchers studying AGTR2, a key receptor involved in the regulation of blood pressure and cardiovascular function. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to the AGTR2 protein, facilitating its detection and analysis in various cell types, making it an ideal choice for studies in cardiovascular research and hypertension.AGTR2, also known as angiotensin II receptor type 2, plays a crucial role in modulating the effects of angiotensin II, a hormone that regulates blood pressure and fluid balance in the body.
Dysregulation of AGTR2 has been implicated in various cardiovascular disorders, making it a promising target for therapeutic interventions. By understanding the function and expression of AGTR2, researchers can gain insights into the pathophysiology of cardiovascular diseases and develop novel treatments to combat them.
Product Name:
AGTR2 Polyclonal Antibody
SKU:
CAB21999
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human AGTR2 (NP_000677.2).
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients.
Purification Method:
Affinity purification
Gene ID:
186
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Hep G2, using AGTR2 Rabbit pAb (CAB21999) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
