The AGTR2 Polyclonal Antibody (CAB16342) is a valuable tool for researchers studying the Angiotensin II Receptor Type 2 (AGTR2) protein, which plays a key role in the regulation of blood pressure and cardiovascular function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the AGTR2 protein, this antibody enables detection and analysis in various cell types, making it ideal for studies in cardiovascular biology and hypertension research.AGTR2 is a G protein-coupled receptor that counteracts the effects of AGTR1, the main receptor responsible for the vasoconstrictive actions of Angiotensin II.
Research on AGTR2 is important for understanding the complex mechanisms involved in blood pressure regulation and cardiovascular disease. By targeting AGTR2, researchers can explore potential therapeutic strategies for conditions like hypertension, heart failure, and vascular disorders.Overall, the AGTR2 Polyclonal Antibody is a valuable tool for investigating the physiological role of AGTR2 and its implications in cardiovascular health. Its high specificity and reactivity make it a reliable choice for researchers seeking to deepen their understanding of this important protein.
Product Name:
AGTR2 Rabbit Polyclonal Antibody
SKU:
CAB16342
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human AGTR2 (NP_000677.2).
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients.
Purification Method:
Affinity purification
Gene ID:
186
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using AGTR2 Rabbit pAb (CAB16342) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
