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Angiotensinogen Rabbit Polyclonal Antibody (CAB15637)

SKU:
CAB15637
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 6 Anti-AGT Antibody CAB15637
  • Cell Biology Antibodies 6 Anti-AGT Antibody CAB15637
  • Cell Biology Antibodies 6 Anti-AGT Antibody CAB15637
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Angiotensinogen Rabbit Polyclonal Antibody
SKU:CAB15637
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-485 of human Angiotensinogen (NP_000020.1).
Sequence:RVYI HPFH LVIH NEST CEQL AKAN AGKP KDPT FIPA PIQA KTSP VDEK ALQD QLVL VAAK LDTE DKLR AAMV GMLA NFLG FRIY GMHS ELWG VVHG ATVL SPTA VFGT LASL YLGA LDHT ADRL QAIL GVPW KDKN CTSR LDAH KVLS ALQA VQGL LVAQ GRAD SQAQ LLLS TVVG VFTA PGLH LKQP FVQG LALY TPVV LPRS LDFT ELDV AAEK IDRF MQAV TGWK TGCS LMGA SVDS TLAF NTYV HFQG KMKG FSLL AEPQ EFWV DNST SVSV PMLS GMGT FQHW SDIQ DNFS VTQV PFTE SACL LLIQ PHYA SDLD KVEG LTFQ QNSL NWMK KLSP RTIH LTMP QLVL QGSY DLQD LLAQ AELP AILH TELN LQKL SNDR IRVG EVLN SIFF ELEA DERE PTES TQQL NKPE VLEV TLNR PFLF AVYD QSAT ALHF LGRV ANPL STA
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100
Synonyms:ANHU; hFLT1; SERPINA8; Angiotensinogen
Positive Sample:Human plasma,Mouse plasma
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:53kDa
Observed MW:53kDa

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Purification Method:Affinity purification
Gene ID:183
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Angiotensinogen Rabbit pAb (CAB15637) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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