The AGR2 Rabbit Monoclonal Antibody is a cutting-edge tool for researchers studying AGR2, a protein known to play a crucial role in cancer development and progression. This antibody, produced using innovative rabbit monoclonal technology, boasts high specificity and sensitivity for detecting AGR2 in human samples, making it a valuable asset in cancer research.AGR2, also known as anterior gradient protein 2 homolog, is involved in various cellular processes, including cell growth, differentiation, and metastasis. Its overexpression has been linked to several types of cancer, making it a potential biomarker for early cancer detection and a target for therapeutic interventions.
The AGR2 Rabbit Monoclonal Antibody enables precise detection and analysis of AGR2 expression in tumor samples, thereby facilitating research into the mechanisms underlying cancer progression.By utilizing this antibody in techniques such as Western blotting and immunohistochemistry, researchers can delve deeper into the role of AGR2 in cancer biology and identify potential therapeutic strategies targeting this important protein. Enhance your cancer research efforts with the AGR2 Rabbit Monoclonal Antibody and unlock new insights into tumor progression and treatment options.
Product Name:
AGR2 Rabbit Monoclonal Antibody
SKU:
CAB12411
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AGR2 (O95994).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
Purification Method:
Affinity purification
Gene ID:
10551
Clone Number:
ARC0709
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HT-29 cells, using AGR2 Rabbit mAb (CAB12411) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
