The AGR2 Polyclonal Antibody (CAB7064) is a valuable tool for researchers studying AGR2, a protein associated with cancer progression and metastasis. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By targeting the AGR2 protein, this antibody enables precise detection and analysis in a variety of cell types, providing insights into the role of AGR2 in cancer biology.AGR2, a member of the protein disulfide isomerase family, is overexpressed in many types of cancer and is believed to promote tumor growth, invasion, and resistance to therapy.
Understanding the mechanisms by which AGR2 contributes to cancer development is essential for the development of targeted treatments and diagnostic tools. The AGR2 Polyclonal Antibody offers a reliable means of studying AGR2 expression levels and subcellular localization, facilitating research into novel therapeutic strategies for combating cancer.
Product Name:
AGR2 Rabbit Polyclonal Antibody
SKU:
CAB7064
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-175 of human AGR2 (NP_006399.1).
HT-29,BT-474,MCF7,NCI-H460,Mouse stomach,Mouse liver,Mouse small intestine,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Endoplasmic reticulum, Secreted.
Calculated MW:
20kDa
Observed MW:
20kDa
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
Purification Method:
Affinity purification
Gene ID:
10551
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AGR2 Rabbit pAb (CAB7064) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
