AGR2 Rabbit Polyclonal Antibody (CAB7064)
- SKU:
- CAB7064
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | AGR2 Rabbit Polyclonal Antibody |
SKU: | CAB7064 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-175 of human AGR2 (NP_006399.1). |
Sequence: | RDTT VKPG AKKD TKDS RPKL PQTL SRGW GDQL IWTQ TYEE ALYK SKTS NKPL MIIH HLDE CPHS QALK KVFA ENKE IQKL AEQF VLLN LVYE TTDK HLSP DGQY VPRI MFVD PSLT VRAD ITGR YSNR LYAY EPAD TALL LDNM KKAL KLLK TEL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AG2; AG-2; HPC8; GOB-4; HAG-2; RIFTD; XAG-2; PDIA17; HEL-S-116; AGR2 |
Positive Sample: | HT-29,BT-474,MCF7,NCI-H460,Mouse stomach,Mouse liver,Mouse small intestine,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Secreted. |
Calculated MW: | 20kDa |
Observed MW: | 20kDa |
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
Purification Method: | Affinity purification |
Gene ID: | 10551 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |