The AGPAT4 Polyclonal Antibody (PACO01027) is a valuable tool for researchers studying AGPAT4, an enzyme involved in lipid metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically recognizes the AGPAT4 protein, enabling precise detection and analysis in a variety of cell types.AGPAT4, also known as 1-acylglycerol-3-phosphate O-acyltransferase 4, plays a pivotal role in the biosynthesis of phospholipids and triglycerides. Dysregulation of AGPAT4 has been implicated in various metabolic disorders and cancer progression, making it a promising target for therapeutic interventions.
Research focused on understanding the function and regulation of AGPAT4 is essential for developing novel treatments for lipid-related diseases.Overall, the AGPAT4 Polyclonal Antibody is a valuable tool for investigating the role of AGPAT4 in lipid metabolism and its implications in human health and disease. Its high specificity and sensitivity make it an ideal choice for studies in biochemistry, molecular biology, and metabolic disorders.
Antibody Name:
AGPAT4 Antibody
Antibody SKU:
PACO01027
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human LPAAT-delta.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
AGPAT4: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Protein type: Transferase; Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - glycerolipid; Lipid Metabolism - ether lipid; EC 2.3.1.51; Lipid Metabolism - glycerophospholipidChromosomal Location of Human Ortholog: 6q26Cellular Component: endoplasmic reticulum membraneMolecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; protein bindingBiological Process: phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
