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AGO2 Antibody (PACO09039)

SKU:
PACO09039
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551
Frequently bought together:

Description

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AGO2 Antibody (PACO09039)

The AGO2 Polyclonal Antibody (PACO09039) is a valuable tool for researchers studying AGO2, a key component of the RNA-induced silencing complex (RISC) involved in RNA interference (RNAi) pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting AGO2, this antibody enables precise detection and analysis of AGO2 protein expression in various cell types, making it well-suited for investigations in RNAi, gene regulation, and viral defense mechanisms.AGO2 is a critical player in post-transcriptional gene silencing processes, contributing to the regulation of gene expression by binding to small RNA molecules and guiding them to their target mRNA sequences for degradation or translational repression.

Its pivotal role in RNAi pathways has important implications for research in areas such as gene therapy, antiviral defense mechanisms, and understanding the molecular basis of diseases like cancer and neurodegenerative disorders. By studying AGO2, researchers can gain insights into the intricate mechanisms of gene regulation and potentially identify new therapeutic targets for various diseases.

Antibody Name:AGO2 Antibody (PACO09039)
Antibody SKU:PACO09039
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human EIF2C2
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:eukaryotic translation initiation factor 2C, 2;EIF2C2;AGO2;MGC3183;Q10 ;
UniProt Protein Function:AGO2: the endonuclease in RNA-induced silencing complexes (RISC) that cleaves siRNA/mRNA heteroduplexes bound to RISC. Ago2, along with Dicer and TRBP, are major components of RISC. Interacts with Dicer1 through its Piwi domain. Required for proper fibroblast growth factor signaling during gastrulation. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi).
UniProt Protein Details:

Protein type:RNA processing; RNA-binding; EC 3.1.26.n2

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: nucleoplasm; polysome; mRNA cap complex; membrane; cytoplasm; ribonucleoprotein complex; cytosol

Molecular Function:mRNA binding; endoribonuclease activity; protein binding; miRNA binding; siRNA binding; translation initiation factor activity; metal ion binding; RNA 7-methylguanosine cap binding

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of translational initiation; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; RNA interference, siRNA loading onto RISC; translation; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, negative regulation of translation; post-embryonic development; regulation of transcription, DNA-dependent; pre-microRNA processing; translational initiation; innate immune response; RNA-mediated gene silencing; gene expression; posttranscriptional gene silencing

NCBI Summary:This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Code:Q9UKV8
NCBI GenInfo Identifier:229463006
NCBI Gene ID:27161
NCBI Accession:Q9UKV8.3
UniProt Secondary Accession:Q9UKV8,Q8TCZ5, Q8WV58, Q96ID1,
UniProt Related Accession:Q9UKV8
Molecular Weight:859
NCBI Full Name:Protein argonaute-2
NCBI Synonym Full Names:argonaute RISC catalytic component 2
NCBI Official Symbol:AGO2  
NCBI Official Synonym Symbols:Q10; EIF2C2  
NCBI Protein Information:protein argonaute-2; PPD; hAgo2; eIF2C 2; eIF-2C 2; argonaute2; argonaute 2; protein slicer; PAZ Piwi domain protein; eukaryotic translation initiation factor 2C, 2
UniProt Protein Name:Protein argonaute-2
UniProt Synonym Protein Names:Argonaute RISC catalytic component 2Eukaryotic translation initiation factor 2C 2; PAZ Piwi domain protein
UniProt Gene Name:AGO2  
UniProt Entry Name:AGO2_HUMAN

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