The Aggrecan Rabbit Monoclonal Antibody is a powerful tool for researchers studying aggrecan, a key proteoglycan component of cartilage tissue. This antibody, produced in rabbits, is highly specific and efficient in detecting aggrecan in a variety of samples, including human tissues and cell lines. It has been validated for use in techniques such as immunofluorescence, immunohistochemistry, and ELISA.Aggrecan is essential for maintaining the structural integrity of cartilage and plays a crucial role in joint health.
Dysregulation of aggrecan expression or function is associated with various cartilage-related diseases, such as osteoarthritis. By using the Aggrecan Rabbit Monoclonal Antibody, researchers can study the expression patterns and localization of aggrecan in different cell types and tissues, providing valuable insights into cartilage biology and potential therapeutic targets for cartilage-related disorders.
Product Name:
Aggrecan Rabbit Monoclonal Antibody
SKU:
CAB11691
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 761-861 of human Aggrecan (P16112).
Sequence:
WPPT GAAT EEST EGPS ATEV PSAS EEPS PSEV PFPS EEPS PSEE PFPS VRPF PSVE LFPS EEPF PSKE PSPS EEPS ASEE PYTP SPPV PSWT ELPS SGEE S
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Purification Method:
Affinity purification
Gene ID:
176
Clone Number:
ARC0678
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using Aggrecan Rabbit mAb (CAB11691) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
