The AGER Polyclonal Antibody (CAB1395) is a valuable tool for researchers studying the AGER gene, which encodes the receptor for advanced glycation end products (RAGE). RAGE is involved in various physiological and pathological processes, including inflammation, cancer, diabetes, and neurodegenerative diseases. This antibody, produced in rabbits, specifically recognizes human AGER protein and is validated for use in Western blot applications. By binding to the AGER receptor, the antibody allows for the detection and analysis of AGER expression in different cell types, making it suitable for investigations in immunology, oncology, and neurobiology.
Understanding the role of AGER and its interaction with advanced glycation end products is crucial for elucidating its involvement in disease pathogenesis and developing targeted therapies. The AGER Polyclonal Antibody is a valuable tool for researchers looking to further explore the functions of RAGE in health and disease.
Product Name:
AGER Rabbit Polyclonal Antibody
SKU:
CAB1395
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-330 of human AGER (NP_001127.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
43kDa
Observed MW:
43kDa
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
Purification Method:
Affinity purification
Gene ID:
177
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AGER antibody (CAB1395) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
