The AGER Polyclonal Antibody (CAB13264) is a valuable tool for researchers studying AGER, a receptor involved in cell signaling and inflammation processes. This antibody, developed in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting.AGER, also known as advanced glycosylation end product-specific receptor, plays a key role in mediating cellular responses to damage caused by high levels of blood sugar. Its involvement in inflammation and tissue damage makes it a promising target for research in diabetes, cardiovascular diseases, and other conditions related to glycation.
By using the AGER Polyclonal Antibody, researchers can effectively detect and analyze the AGER protein in different cell types, enabling a better understanding of its function in health and disease. This antibody is a valuable tool for studies in immunology, diabetes research, and vascular biology, providing insights that may lead to the development of new therapeutic strategies targeting AGER-related pathways.
Product Name:
AGER Rabbit Polyclonal Antibody
SKU:
CAB13264
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-210 of human AGER (NP_001127.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
43kDa
Observed MW:
45kDa/55kDa
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
Purification Method:
Affinity purification
Gene ID:
177
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using AGER Rabbit pAb (CAB13264) at 1:5000/1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
