| UniProt Protein Function: | AGBL5: Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.17.-; ProteaseChromosomal Location of Human Ortholog: 2p23.3Cellular Component: cytoplasm; cytosol; midbody; nucleusMolecular Function: metallocarboxypeptidase activity; tubulin bindingBiological Process: defense response to virus |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q8NDL9 |
| NCBI GenInfo Identifier: | 74715354 |
| NCBI Gene ID: | 60509 |
| NCBI Accession: | Q8NDL9.1 |
| UniProt Secondary Accession: | Q8NDL9,Q53SW0, Q53SZ0, Q96IK8, Q9H6V0, Q9H8P8, A2VDI7 B7WPG9, B7Z7I7, D6W548 |
| UniProt Related Accession: | Q8NDL9 |
| Molecular Weight: | 80,016 Da |
| NCBI Full Name: | Cytosolic carboxypeptidase-like protein 5 |
| NCBI Synonym Full Names: | ATP/GTP binding protein like 5 |
| NCBI Official Symbol: | AGBL5Â Â |
| NCBI Official Synonym Symbols: | CCP5; RP75Â Â |
| NCBI Protein Information: | cytosolic carboxypeptidase-like protein 5 |
| UniProt Protein Name: | Cytosolic carboxypeptidase-like protein 5 |
| UniProt Synonym Protein Names: | ATP/GTP-binding protein-like 5 |
| Protein Family: | Cytosolic carboxypeptidase-like protein |
| UniProt Gene Name: | AGBL5Â Â |
| UniProt Entry Name: | CBPC5_HUMAN |
