The AGBL3 Polyclonal Antibody (PAC015345) is a valuable tool for researchers studying AGBL3, a member of the ATPase family known for its roles in microtubule dynamics and cell division. This antibody, produced in rabbits, is highly sensitive and specific for detecting AGBL3 in human samples, making it ideal for Western blot applications. By targeting the AGBL3 protein, researchers can investigate its function in various cell types, providing insights into its role in cellular processes such as microtubule regulation and mitosis.
AGBL3 is a key player in cell division and has been shown to be dysregulated in various cancer types, making it a promising target for cancer research. Understanding the mechanisms by which AGBL3 influences cell division and tumor growth is crucial for developing novel therapeutic strategies to target this protein in cancer treatment. The AGBL3 Polyclonal Antibody offers researchers a reliable tool to unravel the complex functions of AGBL3 in cancer biology and potentially identify new avenues for cancer therapy.
Gel: 8+12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: PACO15345(AGBL3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15345(AGBL3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This protein belongs to the peptidase M14 family. It has a function in the processing of cytosolic proteins such as alpha-tubulin, which is known to be modified by the removal of a C-terminal tyrosine. Evrey subunit binds 1 zinc ion. It has high levels expression in digestive and blood/hematopoietic system, like intestine, urinary, kidney and bone marrow.
Synonyms:
ATP/GTP binding protein-like 3
UniProt Protein Function:
AGBL3: Metallocarboxypeptidase that may play a role in the processing of tubulin. Belongs to the peptidase M14 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protease; EC 3.4.17.-Chromosomal Location of Human Ortholog: 7q33Cellular Component: cytosolMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: proteolysis