The AGBL1 Polyclonal Antibody (PAC018528) is a valuable tool for researchers studying the AGBL1 protein, a key player in various cellular processes including cell proliferation, migration, and apoptosis. This antibody, produced in rabbits, has been validated for use in Western blot applications and exhibits high reactivity with human samples.AGBL1, also known as ATP/GTP binding protein-like 1, is involved in regulating microtubule dynamics and has been implicated in cancer progression and metastasis. By targeting the AGBL1 protein, researchers can gain insights into its function in both normal and disease states, particularly in the context of cancer research.
Understanding the role of AGBL1 may lead to the development of novel therapeutic strategies for treating cancer and other related conditions.Overall, the AGBL1 Polyclonal Antibody is a versatile tool for investigating the functions and mechanisms of AGBL1, providing valuable information for research in cancer biology and cell biology. Its specificity and reliability make it an essential component in studies aimed at unraveling the complexities of AGBL1-mediated pathways.
Antibody Name:
AGBL1 Antibody (PACO18528)
Antibody SKU:
PACO18528
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:15-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human AGBL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18528(AGBL1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18528(AGBL1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Synonyms:
ATP/GTP binding protein-like 1
UniProt Protein Function:
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
UniProt Protein Details:
NCBI Summary:
Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]
