The AFG3L2 Polyclonal Antibody (CAB15393) is a valuable tool for researchers studying AFG3L2, a protein involved in mitochondrial protein quality control and maintenance. This antibody, generated in rabbits, is highly specific to human AFG3L2 and has been validated for use in Western blot applications. By binding to the AFG3L2 protein, this antibody enables researchers to detect and analyze AFG3L2 levels in a variety of cell types, making it ideal for studies in mitochondrial biology and neurodegenerative diseases.AFG3L2 plays a crucial role in maintaining mitochondrial function and protecting cells from stress-induced damage. Dysregulation of AFG3L2 has been linked to neurodegenerative disorders such as spinocerebellar ataxia and hereditary spastic paraplegia.
By studying the activity and expression of AFG3L2, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets for treatment.Overall, the AFG3L2 Polyclonal Antibody is a reliable tool for investigating the function of AFG3L2 in cellular processes and disease pathology. Its high specificity and sensitivity make it a valuable asset for researchers seeking to deepen their understanding of mitochondrial biology and develop new strategies for combating neurodegenerative disorders.
Product Name:
AFG3L2 Rabbit Polyclonal Antibody
SKU:
CAB15393
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 538-797 of human AFG3L2 (NP_006787.2).
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
Purification Method:
Affinity purification
Gene ID:
10939
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using AFG3L2 Rabbit pAb (CAB15393) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
