The AFG3L2 Polyclonal Antibody (ABG10010) offered by Assay Genie is a valuable tool for researchers studying the AFG3L2 protein, which plays a key role in mitochondrial function and protein quality control. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for use in Western blot applications. By targeting the AFG3L2 protein, this antibody enables precise detection and analysis in various cell types, aiding in investigations related to mitochondrial biology, neurodegenerative diseases, and protein degradation pathways.AFG3L2 is a conserved mitochondrial ATP-dependent metalloprotease, essential for maintaining mitochondrial homeostasis and cellular function.
Dysregulation of AFG3L2 has been implicated in various pathologies, including neurodegenerative disorders like Parkinson's disease and mitochondrial myopathies. Therefore, exploring the functions and regulatory mechanisms of AFG3L2 is critical for advancing our understanding of these conditions and developing targeted therapeutic interventions.In conclusion, the AFG3L2 Polyclonal Antibody from Assay Genie offers researchers a reliable tool for studying the AFG3L2 protein and its implications in mitochondrial biology and disease pathology. Its high specificity and reactivity make it a valuable asset for research in a wide range of biological contexts.
Product Name:
AFG3L2 Polyclonal Antibody
SKU:
CAB23598
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 538-797 of human AFG3L2（NP_006787.2）.
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
Purification Method:
Affinity purification
Gene ID:
10939
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using AFG3L2 Rabbit pAb (CAB23598) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
