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Low Endotoxin Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1624)

SKU:
AGEL1624
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€229 - €1,219
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Description

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Low Endotoxin Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody (29F.1A12) is a specialized tool for researchers studying immune checkpoints, particularly the PD-1 pathway. This antibody targets the CD279 protein, a key player in immune regulation and tolerance. It is purified from mouse hybridoma culture supernatant, ensuring high specificity and sensitivity in detecting PD-1 in various biological samples.PD-1, also known as programmed cell death protein 1, is a crucial checkpoint receptor that inhibits T cell activation and prevents autoimmunity. Dysregulation of the PD-1 pathway is implicated in various diseases, including cancer and chronic infections.

By using this monoclonal antibody, researchers can accurately monitor PD-1 expression levels, investigate its role in immune responses, and explore potential therapeutic interventions targeting the PD-1 pathway.With its reliable performance in techniques such as flow cytometry, immunofluorescence, and immunohistochemistry, the Mouse CD279 (PD-1) Monoclonal Antibody (29F.1A12) is a valuable asset for immunologists, oncologists, and researchers delving into the intricate mechanisms of immune tolerance and immune evasion in disease settings.

Product Title:Low Endotoxin Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1624
Size:50µg, 500µg, 1mg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM;Block;Neut
Isotype:Rat IgG2a, κ
Isotype Control:AF/LE Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q02242
Gene ID:18566
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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