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Low Endotoxin Purified Anti-Mouse TCR ?/δ Antibody [UC7-13D5] (AGEL2245)

SKU:
AGEL2245
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Armenian Hamster
Isotype:
Armenian Hamster IgG
Clone:
UC7-13D5
Conjugation:
None (Low endotoxin)
€189 - €929
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse TCR γ/δ Antibody [UC7-13D5]

The AF-Le Purified Anti-Mouse TCR Antibody (UC7-13D5) is a highly specific and potent tool for researchers studying T-cell receptor (TCR) biology in mouse models. This monoclonal antibody, purified using advanced techniques, targets the TCR complex, which is essential for T-cell recognition and activation.TCRs play a pivotal role in adaptive immune responses by enabling T-cells to identify and respond to specific antigens. The UC7-13D5 antibody binds specifically to the mouse TCR, facilitating the detection and characterization of TCR-expressing cells in experimental settings. Its high affinity and selectivity make it a reliable reagent for applications such as flow cytometry, immunofluorescence, and immunohistochemistry.

Researchers investigating T-cell function, antigen recognition, and immune responses in mouse models will find the AF-Le Purified Anti-Mouse TCR Antibody (UC7-13D5) to be a valuable asset in their studies. By elucidating the mechanisms underlying TCR signaling and activation, this antibody contributes to our understanding of immune responses and may aid in the development of novel immunotherapies for diseases such as cancer, infections, and autoimmune disorders.

Product Title:Low Endotoxin Purified Anti-Mouse TCR γ/δ Antibody [UC7-13D5]
SKU:AGEL2245
Size:50µg, 500µg, 1mg
Clone No:UC7-13D5
Synonyms:TCR-γ/δ; γ/δ TCR;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:AF/LE Purified Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Gene ID:110066,110067
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.

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