Low Endotoxin Purified Anti-Mouse CD86 Antibody [GL-1] (AGEL2144)
- SKU:
- AGEL2144
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- Rat IgG2a, κ
- Clone:
- GL-1
- Conjugation:
- None (Low endotoxin)
Frequently bought together:
Description
Product Title: | Low Endotoxin Purified Anti-Mouse CD86 Antibody [GL-1] |
SKU: | AGEL2144 |
Size: | 50µg, 500µg, 1mg |
Clone No: | GL-1 |
Synonyms: | T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1; |
Host Species: | Rat |
Reactivity: | Mouse |
Application: | FCM |
Isotype: | Rat IgG2a, κ |
Isotype Control: | AF/LE Purified Rat IgG2a, κ Isotype Control[2A3] |
Form: | Liquid |
Conjugation: | None (AF/LE) |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Swissprot: | P42082 |
Gene ID: | 12524 |
Storage Buffer: | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. |