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Low Endotoxin Purified Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL2360)

SKU:
AGEL2360
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Block
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
RMT3-23
Conjugation:
None (Low endotoxin)
€229 - €1,219
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The RMT3-23 Purified Anti-Mouse CD366 (TIM-3) Antibody is a cutting-edge tool designed for researchers studying the CD366 (TIM-3) protein, a key immune checkpoint receptor involved in immune regulation and exhaustion. This antibody, meticulously purified and validated for mouse samples, offers exceptional specificity and sensitivity for various experimental applications, including flow cytometry, immunofluorescence, and immunohistochemistry.CD366, also known as T-cell immunoglobulin and mucin domain 3, plays a pivotal role in T-cell function and tolerance by regulating immune responses and T-cell exhaustion. Its interactions with ligands such as galectin-9 have been linked to immune evasion and dysfunction in the context of cancer, chronic infections, and autoimmune diseases.

The ability to detect and analyze CD366 expression in immune cells is crucial for unraveling its complex mechanisms and developing targeted therapies that modulate immune responses effectively.With its advanced purification process and extensive validation, the RMT3-23 Purified Anti-Mouse CD366 (TIM-3) Antibody provides researchers with a reliable tool to deepen their understanding of immune checkpoint pathways and explore innovative strategies for immunotherapy and treating immune-related disorders.

Product Title:Low Endotoxin Purified Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:AGEL2360
Size:50µg, 500µg, 1mg
Clone No:RMT3-23
Synonyms:TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:Rat
Reactivity:Mouse
Application:FCM;Block
Isotype:Rat IgG2a, κ
Isotype Control:AF/LE Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q8VIM0
Gene ID:84868
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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