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Low Endotoxin Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL2259)

SKU:
AGEL2259
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Block
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, κ
Clone:
10F.9G2
Conjugation:
None (Low endotoxin)
€189 - €929
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The AFLE Purified Anti-Mouse CD274 (PD-L1) Antibody 10F.9G2 is a vital tool for researchers investigating immune checkpoint pathways and immune regulation in mice. This antibody specifically targets the CD274 (PD-L1) protein, which is known for its role in suppressing immune responses and promoting immune tolerance.PD-L1, a key player in the PD-1/PD-L1 pathway, is crucial for maintaining immune balance and preventing excessive immune activation. By binding to PD-1 on T cells, PD-L1 inhibits T cell proliferation and cytokine production, thus playing a crucial role in immune evasion by cancer cells and other immune-related disorders.The AFLE Anti-Mouse CD274 (PD-L1) Antibody 10F.9G2 is purified and highly specific for mouse samples, allowing for accurate detection and quantification of PD-L1 expression in various cell types and tissues.

This antibody is validated for use in a range of applications, including flow cytometry, immunohistochemistry, and Western blotting, making it an essential tool for studies focused on immune checkpoint blockade, cancer immunotherapy, and autoimmune diseases in mouse models.By targeting PD-L1, researchers can gain valuable insights into the mechanisms of immune suppression and develop novel therapeutic strategies to modulate immune responses in conditions such as cancer, infectious diseases, and autoimmune disorders. The AFLE Anti-Mouse CD274 (PD-L1) Antibody 10F.9G2 offers reliable and specific detection of PD-L1, facilitating in-depth studies of immune checkpoint pathways and their implications in disease pathogenesis.

Product Title:Low Endotoxin Purified Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL2259
Size:50µg, 500µg, 1mg
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM;Block
Isotype:Rat IgG2b, κ
Isotype Control:AF/LE Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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