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Low Endotoxin Purified Anti-Mouse CD22 Antibody [Cy34.1] (AGEL2157)

SKU:
AGEL2157
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
Cy34.1
Conjugation:
None (Low endotoxin)
€189 - €929
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD22 Antibody [Cy34.1]

The Purified Anti-Mouse CD22 Antibody (CY34.1) offered by AssayGenie is a high-quality research tool designed for studying the CD22 protein in mouse samples. CD22 is a cell surface molecule known to be involved in B cell function and regulation. This antibody, purified and specifically developed for mouse samples, is highly specific and sensitive, making it a reliable tool for various research applications.The CY34.1 antibody is ideal for detecting and analyzing the CD22 protein in different cell types, enabling researchers to gain insights into its role in B cell biology, immune responses, and potential implications in diseases such as leukemia and autoimmune disorders.

This antibody has been rigorously validated for use in techniques like immunohistochemistry, flow cytometry, and Western blot, providing researchers with flexibility in their experimental approaches.By using the Purified Anti-Mouse CD22 Antibody (CY34.1) from AssayGenie, researchers can delve deeper into the functions and mechanisms of CD22 in mouse models, contributing to a better understanding of B cell biology and the development of targeted therapies for related diseases.

Product Title:Low Endotoxin Purified Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL2157
Size:50µg, 500µg, 1mg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:AF/LE Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P35329
Gene ID:12483
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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