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Low Endotoxin Purified Anti-Mouse CD119 Antibody [GR-20] (AGEL2218)

SKU:
AGEL2218
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
GR-20
Conjugation:
None (Low endotoxin)
€189 - €929
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD119 Antibody [GR-20]

The AF-LE Purified Anti-Mouse CD119 Antibody (GR-20) offered by Assay Genie is a high-quality research tool designed for investigating CD119, a crucial cell surface receptor involved in immune responses. This extensively validated antibody, produced through purification processes, exhibits exceptional reactivity with mouse samples and is particularly suitable for use in various immunological research applications, including flow cytometry and immunohistochemistry.CD119, also known as the Interleukin-2 receptor subunit alpha (IL-2RA), plays a pivotal role in immune system function by facilitating signaling cascades that regulate immune cell activation and proliferation. By specifically targeting and binding to CD119, the GR-20 antibody enables precise detection and analysis of this important receptor on different cell types, offering researchers a valuable tool for studying immune responses, autoimmunity, and inflammatory processes in murine models.

Given the central role of CD119 in immune regulation, this antibody is essential for researchers exploring the mechanisms underlying immune-mediated diseases such as autoimmune disorders, inflammatory conditions, and cancer. Understanding the intricacies of CD119 signaling pathways is critical for the development of targeted therapeutic interventions that modulate immune responses effectively. With its exceptional specificity and reliability, the AF-LE Purified Anti-Mouse CD119 Antibody (GR-20) is an indispensable asset for advancing research in the field of immunology and beyond.

Product Title:Low Endotoxin Purified Anti-Mouse CD119 Antibody [GR-20]
SKU:AGEL2218
Size:50µg, 500µg, 1mg
Clone No:GR-20
Synonyms:Interferon gamma receptor 1;Ifngr1;IFN-gamma-R1;IFN-gamma-R-alpha;CD119;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:AF/LE Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P15261
Gene ID:15979
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.

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