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Low Endotoxin Purified Anti-Mouse CD103 Antibody [M290] (AGEL2177)

SKU:
AGEL2177
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Block
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
M290
Conjugation:
None (Low endotoxin)
€189 - €929
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD103 Antibody [M290]

The AFLE Purified Anti-Mouse CD103 Antibody (M290) offered by Assay Genie is a valuable tool for researchers studying immune responses in mouse models. This monoclonal antibody specifically targets the CD103 protein, a cell surface marker known for its role in regulating immune cell migration and tissue residency.Developed for use in various experimental techniques such as flow cytometry, immunohistochemistry, and functional assays, the M290 antibody is highly specific and sensitive. Its reactivity with mouse samples has been thoroughly validated, ensuring reliable and consistent results for researchers exploring immune cell behavior and function.

By targeting CD103, researchers can gain insights into the functions of immune cells in tissues, particularly in the context of infection, inflammation, and autoimmune conditions. The AFLE Purified Anti-Mouse CD103 Antibody (M290) represents a valuable tool for studies in immunology, cancer biology, and beyond, enabling detailed analysis of immune cell populations and their interactions within the microenvironment.

Product Title:Low Endotoxin Purified Anti-Mouse CD103 Antibody [M290]
SKU:AGEL2177
Size:50µg, 500µg, 1mg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM;Block
Isotype:Rat IgG2a, κ
Isotype Control:AF/LE Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q60677
Gene ID:16407
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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