The ADRM1 Polyclonal Antibody (CAB4481) is a valuable tool for researchers studying ADRM1, a crucial component of the ubiquitin-proteasome system involved in protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ADRM1 protein, this antibody enables the detection and analysis of ADRM1 in a variety of cell types, making it ideal for studies in molecular biology and protein degradation pathways.ADRM1, also known as the Proteasome 19S Regulatory Particle Non-ATPase Subunit 1, plays a key role in protein turnover by facilitating the recognition and processing of ubiquitinated substrates for degradation.
Dysregulation of ADRM1 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its importance as a potential therapeutic target. By investigating the function and regulation of ADRM1, researchers can gain insights into mechanisms of disease pathogenesis and potentially identify novel treatment strategies.
Product Name:
ADRM1 Rabbit Polyclonal Antibody
SKU:
CAB4481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 108-407 of human ADRM1 (NP_008933.2).
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11047
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADRM1 Rabbit pAb (CAB4481) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
