The ADRBK2 Polyclonal Antibody (CAB2049) is a valuable tool for researchers studying ADRBK2, a protein involved in regulating signaling pathways in cells. This antibody, produced in rabbits, has high reactivity with human samples and is optimized for use in Western blot applications. By binding to the ADRBK2 protein, this antibody allows for the detection and analysis of ADRBK2 in a variety of cell types, making it ideal for studies in cell signaling, protein regulation, and disease mechanisms.ADRBK2, also known as beta-adrenergic receptor kinase 2, plays a crucial role in regulating the desensitization of beta-adrenergic receptors, which are involved in processes such as heart rate and blood pressure regulation.
Dysregulation of ADRBK2 has been implicated in various diseases, including cardiovascular disorders and neurological conditions. By studying the function of ADRBK2, researchers can gain insights into potential therapeutic targets for these diseases and develop strategies for modulating signaling pathways that involve this protein.
Product Name:
ADRBK2 Rabbit Polyclonal Antibody
SKU:
CAB2049
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ADRBK2 (NP_005151.2).
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Purification Method:
Affinity purification
Gene ID:
157
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADRBK2 Rabbit pAb (CAB2049) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
