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[KO Validated] GRK2 Rabbit Polyclonal Antibody (CAB1662)

SKU:
CAB1662
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-ADRBK1 Antibody CAB1662KO Validated
  • KO Validated Antibodies 1 Anti-ADRBK1 Antibody CAB1662KO Validated
  • KO Validated Antibodies 1 Anti-ADRBK1 Antibody CAB1662KO Validated
  • KO Validated Antibodies 1 Anti-ADRBK1 Antibody CAB1662KO Validated
  • KO Validated Antibodies 1 Anti-ADRBK1 Antibody CAB1662KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] GRK2 Rabbit Polyclonal Antibody
SKU:CAB1662
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 440-689 of human GRK2 (NP_001610.2).
Sequence:LGRG AQEV KESP FFRS LDWQ MVFL QKYP PPLI PPRG EVNA ADAF DIGS FDEE DTKG IKLL DSDQ ELYR NFPL TISE RWQQ EVAE TVFD TINA ETDR LEAR KKAK NKQL GHEE DYAL GKDC IMHG YMSK MGNP FLTQ WQRR YFYL FPNR LEWR GEGE APQS LLTM EEIQ SVEE TQIK ERKC LLLK IRGG KQFI LQCD SDPE LVQW KKEL RDAY REAQ QLVQ RVPK MKNK PRSP VVEL SKVP LVQR GSAN GL
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:BARK1; ADRBK1; BETA-ARK1; K2
Positive Sample:HT-29,Mouse spleen,Mouse brain
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm.
Calculated MW:80kDa
Observed MW:80kDa

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.

Purification Method:Affinity purification
Gene ID:156
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] GRK2 Rabbit pAb (CAB1662) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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