ADRB2 Rabbit Polyclonal Antibody (CAB2048)
- SKU:
- CAB2048
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ADRB2 Rabbit Polyclonal Antibody |
SKU: | CAB2048 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ADRB2 (NP_000015.1). |
Sequence: | DNLI RKEV YILL NWIG YVNS GFNP LIYC RSPD FRIA FQEL LCLR RSSL KAYG NGYS SNGN TGEQ SGYH VEQE KENK LLCE DLPG TEDF VGHQ GTVP SDNI D |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | BAR; B2AR; ADRBR; ADRB2R; BETA2AR; ADRB2 |
Positive Sample: | PC-3,LNCaP,Mouse liver,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Early endosome, Multi-pass membrane protein. |
Calculated MW: | 46kDa |
Observed MW: | 50-100kDa |
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease.
Purification Method: | Affinity purification |
Gene ID: | 154 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |