The ADRB2 Polyclonal Antibody (CAB2048) is specifically designed for research involving ADRB2, a cell surface receptor involved in various physiological functions, including cardiovascular regulation, bronchodilation, and metabolic effects. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding to the ADRB2 protein, this antibody enables the detection and analysis of ADRB2 expression in different cell types, making it an ideal tool for studies in pharmacology, cardiology, and respiratory research.
ADRB2, also known as the beta-2 adrenergic receptor, is a key target for drugs used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), and cardiovascular conditions. Understanding the function and regulation of ADRB2 can provide valuable insights into the mechanisms of these diseases and facilitate the development of more effective therapies. Research using the ADRB2 Polyclonal Antibody (CAB2048) can contribute to advancements in personalized medicine and the identification of novel therapeutic strategies targeting ADRB2 signaling pathways.
Product Name:
ADRB2 Rabbit Polyclonal Antibody
SKU:
CAB2048
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ADRB2 (NP_000015.1).
Cell membrane, Early endosome, Multi-pass membrane protein.
Calculated MW:
46kDa
Observed MW:
50-100kDa
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease.
Purification Method:
Affinity purification
Gene ID:
154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADRB2 Rabbit pAb (CAB2048) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
