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Adrb2 Antibody (PACO24795)

SKU:
PACO24795
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Adrb2 Antibody (PACO24795)

The ADRB2 Polyclonal Antibody (PAC024795) is a versatile tool for researchers studying the adrenergic beta-2 receptor (ADRB2), a key player in the regulation of cardiovascular and respiratory functions. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the ADRB2 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating investigations in the fields of cardiology, pulmonology, and pharmacology.

ADRB2 is a crucial component of the sympathetic nervous system, mediating the effects of adrenaline and noradrenaline on the heart, lungs, and other tissues. Dysregulation of ADRB2 signaling has been implicated in various cardiovascular and respiratory disorders, making it an important therapeutic target for conditions such as heart failure, asthma, and COPD. Research on ADRB2 is essential for developing novel treatments that modulate its activity, potentially leading to improved outcomes for patients with these conditions.

Antibody Name:Adrb2 Antibody (PACO24795)
Antibody SKU:PACO24795
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Beta-2 adrenergic receptor protein (330-418AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Synonyms:Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor), Adrb2, Adrb2r
UniProt Protein Function:ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-passCellular Component: intracellular membrane-bound organelle; integral to plasma membrane; dendrite; integral to membrane; dendritic spine; caveola; membrane; axon; apical plasma membrane; cytoplasm; plasma membrane; nucleus; endosome; sarcolemma; receptor complexMolecular Function: protein homodimerization activity; G-protein alpha-subunit binding; norepinephrine binding; drug binding; epinephrine binding; PDZ domain binding; ionotropic glutamate receptor binding; protein binding; potassium channel regulator activity; enzyme binding; protein complex binding; dopamine binding; beta2-adrenergic receptor activity; B2 bradykinin receptor binding; adenylate cyclase bindingBiological Process: diet induced thermogenesis; wound healing; positive regulation of apoptosis; regulation of vasodilation; positive regulation of potassium ion transport; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; female pregnancy; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of MAPKKK cascade; diaphragm contraction; negative regulation of smooth muscle contraction; positive regulation of cell proliferation; negative regulation of ossification; associative learning; aging; bone resorption; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; regulation of smooth muscle contraction; synaptic transmission, glutamatergic; receptor-mediated endocytosis; negative regulation of multicellular organism growth; adenylate cyclase activation; regulation of calcium ion transport; response to testosterone stimulus; regulation of sodium ion transport; liver development; positive regulation of bone mineralization; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of the force of heart contraction by epinephrine; positive regulation of ATPase activity; response to estrogen stimulus; positive regulation of protein ubiquitination; negative regulation of inflammatory response; heat generation; brown fat cell differentiation; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to cold; regulation of sensory perception of pain; response to progesterone stimulus; positive regulation of skeletal muscle growth; regulation of excitatory postsynaptic membrane potential; positive regulation of heart contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
UniProt Protein Details:
NCBI Summary:binds adrenergic receptor agonist zinterol; plays a role in G-protein coupled receptor regulation of calcium channel current [RGD, Feb 2006]
UniProt Code:P10608
NCBI GenInfo Identifier:114768
NCBI Gene ID:24176
NCBI Accession:P10608.1
UniProt Secondary Accession:P10608,Q6LCR3
UniProt Related Accession:P10608
Molecular Weight:27kD
NCBI Full Name:Beta-2 adrenergic receptor
NCBI Synonym Full Names:adrenoceptor beta 2, surface
NCBI Official Symbol:Adrb2  
NCBI Official Synonym Symbols:
NCBI Protein Information:beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; adrenergic receptor, beta 2; Adrenergic beta 2- receptor surface; adrenergic, beta-2-, receptor, surface
UniProt Protein Name:Beta-2 adrenergic receptor
UniProt Synonym Protein Names:Beta-2 adrenoreceptor
Protein Family:Beta-2 adrenergic receptor
UniProt Gene Name:Adrb2  
UniProt Entry Name:ADRB2_RAT

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