The Adra2c Polyclonal Antibody (CAB16956) is a valuable tool for researchers studying the Adra2c protein, a member of the adrenergic receptor family involved in regulating neurotransmitter release and various physiological functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.By specifically binding to the Adra2c protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in neuroscience, pharmacology, and endocrinology. The Adra2c receptor is known for its role in modulating stress responses, blood pressure regulation, and behavioral functions, making it a promising target for research into conditions such as anxiety disorders, hypertension, and depression.
Understanding the function and regulation of the Adra2c receptor is essential for developing targeted therapies that can modulate its activity and potentially provide new treatment options for a range of disorders. With its high specificity and performance in Western blot applications, the Adra2c Polyclonal Antibody (CAB16956) is a valuable resource for scientists seeking to uncover the intricacies of Adra2c signaling pathways and its implications for human health.
Product Name:
ADRA2C Rabbit Polyclonal Antibody
SKU:
CAB16956
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2C (NP_000674.2).
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
Purification Method:
Affinity purification
Gene ID:
152
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADRA2C Rabbit pAb (CAB16956) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
