ADRA2C Rabbit Polyclonal Antibody (CAB16956)
- SKU:
- CAB16956
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | ADRA2C Rabbit Polyclonal Antibody |
SKU: | CAB16956 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2C (NP_000674.2). |
Sequence: | RTRT LSEK RAPV GPDG ASPT TENG LGAA AGAG ENGH CAPP PADV EPDE SSAA AERR RRRG ALRR GGRR RAGA EGGA GGAD GQGA GPGA AESG ALTA SRSP GPGG RLSR ASSR SVEF FLSR RRRA RSSV CRRK VAQA REKR F |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR; ADRA2C |
Positive Sample: | 293T,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, endosome, plasma membrane |
Calculated MW: | 50kDa |
Observed MW: | 50kDa |
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
Purification Method: | Affinity purification |
Gene ID: | 152 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |