The Adra2A Polyclonal Antibody (CAB2809) is a valuable tool for researchers studying the Adra2a protein, a member of the G protein-coupled receptor family known to be involved in various physiological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By specifically binding to the Adra2a protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an ideal choice for studies in neuroscience, pharmacology, and related fields.
The Adra2a protein is known to play a role in neurotransmission, behavior, and cardiovascular regulation, making it an important target for research on conditions such as depression, anxiety, and hypertension.Overall, the Adra2A Polyclonal Antibody (CAB2809) is a valuable tool for investigating the functions and mechanisms of the Adra2a protein, shedding light on its potential roles in health and disease. Its reliable performance and specificity make it a key asset for researchers aiming to deepen their understanding of this important receptor.
Product Name:
ADRA2A Rabbit Polyclonal Antibody
SKU:
CAB2809
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2A (NP_000672.3).
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established.
Purification Method:
Affinity purification
Gene ID:
150
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADRA2A antibody (CAB2809) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
