ADRA2A Rabbit Polyclonal Antibody (CAB2809)
- SKU:
- CAB2809
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ADRA2A Rabbit Polyclonal Antibody |
SKU: | CAB2809 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2A (NP_000672.3). |
Sequence: | RRTR VPPS RRGP DAVA APPG GTER RPNG LGPE RSAG PGGA EAEP LPTQ LNGA PGEP APAG PRDT DALD LEES SSSD HAER PPGP RRPE RGPR GKGK ARAS QVKP GDSL PRRG PGAT GIGT PAAG PGEE RVGA AKAS RWRG R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR; ADRA2A |
Positive Sample: | K-562,Mouse brain,Mouse Spinal cord |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 51kDa |
Observed MW: | 49kDa |
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established.
Purification Method: | Affinity purification |
Gene ID: | 150 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |