The ADPRHL2 Polyclonal Antibody (PACO19150) is a valuable tool for researchers studying ADPRHL2, a protein involved in ADP-ribosylation, a post-translational modification that regulates various cellular processes. This rabbit polyclonal antibody is highly specific to human ADPRHL2 and has been validated for use in Western blot applications. By binding to the ADPRHL2 protein, this antibody enables the detection and analysis of ADPRHL2 levels in different cell types, making it an ideal choice for studies in molecular biology and cellular signaling pathways.ADPRHL2, also known as ADP-ribosylhydrolase like 2, is a key enzyme involved in the regulation of ADP-ribosylation, a process that plays a role in DNA repair, gene regulation, and other cellular functions.
Dysregulation of ADPRHL2 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Investigating the function of ADPRHL2 can provide important insights into these disease processes and may lead to the development of novel therapeutic strategies targeting ADP-ribosylation pathways.By using the ADPRHL2 Polyclonal Antibody (PACO19150) in your research, you can explore the role of ADPRHL2 in cellular physiology and disease pathogenesis, ultimately contributing to our understanding of ADP-ribosylation biology and its implications for human
Antibody Name:
ADPRHL2 Antibody (PACO19150)
Antibody SKU:
PACO19150
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ADPRHL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, mouse kidney tissue, Primary antibody: PACO19150(ADPRHL2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm. Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.
Synonyms:
ADP-ribosylhydrolase like 2
UniProt Protein Function:
ADPRHL2: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Belongs to the ADP-ribosylglycohydrolase family.Protein type: Hydrolase; EC 3.2.1.143Chromosomal Location of Human Ortholog: 1p34.3Cellular Component: nucleoplasm
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
